EVALUATION OF SERUM LIPID PROFILE IN WOMEN WITH PREECLAMPSIA IN FEDERAL MEDICAL CENTRE, OWERRI: A CASE CONTROL STUDY
Introduction: Preeclampsia is one of the commonest medical disorders in pregnancy occuring in the second half of pregnancy and clinically manifests as hypertension and proteinuria. It occurs in upto 8% of pregnancies worldwide and it’s complications accounts for about 11% of maternalmortality in Nigeria.
Aim: This sudy was done to estimate the serum lipid levels in women with preeclampsia and normotensive pregnancy.
Method: It was a case control study in which 116 subjects were recruited; 58 preeclamptic and 58 normotensive (control group) pregnant women at Federal Medical center, Owerri. 5mls of their venous blood was collected after an overnight fast of 8-12 hours and this was analysed for triglyceride(TG), total cholesterol (TC), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C) using standard enzymatic methods.
Result: There was statistically significant difference in the levels of triglyceride (TG) and very low density lipoprotein (VLDL-C) between the preeclamptics and their normotensive control (P =0.002, P = 0.002 respectively). Furthermore, on Pearson’s correlation, there was a positivecorrelation between these lipids and the severity of the disease.
Concluson: lipid have a role in the etiopthogeneis of preeclampsia and can be assessed in the management of the disease.
Recommendations: Testing the triglyceride and very low density lipoprotein levels will be useful in the early detection of the disease and subsequently improve the outcome.