PATTERN OF SERUM ANTI-MULLERIAN HORMONE AMONG NIGERIAN INFERTILE WOMEN IN LAGOS ISLAND MATERNITY HOSPITAL
Infertility is a major concern for couples with such a medical problem especially in Africa continent where procreation is used as a criterion for a successful marriage. The incidence of infertility in Nigeria varies from 20-30% and about 30-40% of women in Sub Saharan Africa will go through their reproductive phase without having a child. The prevalence of infertility is approximately 18% with a range 7-28% depending on the age of the woman. Ovarian reserve is a term used to determine the capacity of the ovary to provide oocytes that are capable of fertilization resulting in healthy and successful pregnancy. It represents the remaining follicular pool of oocytes in the ovaries that undergo progressive atresia through apoptosis during awoman’s reproductive period. The ovarian follicle pool declines with increasing maternal ageresulting in decrease of a woman’s reproductive potential. There is no direct method forassessing ovarian reserve. However, there are postulated means that can be used to indirectly assess the ovarian reserve which are Biochemical and Radiological. One of biochemical Method involves checking the value of Anti-mullerian hormone (AMH). Women with poor ovarian reserve are less likely to conceive with infertility treatment so they are probably be best advisedon assisted reproductive technique with egg donor. The study was done to determine the ‘Patternof serum Anti-mullerian hormone among Nigeria infertile women in the age range 21-45years presenting at Gynaecology clinic of Lagos Island Maternity Hospital.
STUDY DESIGN, SETTING AND SUBJECTS
This was an Analytical case control study. 300 patients were recruited; 200 for the test were patients with infertility and 100 as control were patients with proven fertility attending the family planning clinic. Both groups were patients of Lagos Island Maternity hospital, Campbell Street, Lagos. Following standard routine history, administration of questionnaire and physical examination, blood samples were obtained for the measurement of serum AMH. Analysis was done by Elisa colorimetric assay method. Results are presented as means ± SD.
RESULTS AND CONCLUSION
Serum AMH levels reduced with age in both infertile and fertile groups and were lower in the control group than the test group but the values were still within normal limits. The range of AMH value of the infertile patients between age 21-45years was between 1.12 – 4.13ng/ml.